Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Blood DNA methylation profiles in a Dutch population

ABSTRACT: Genome wide DNA methylation profiling of whole blood in schizophrenia patients and healthy subjects of different ages. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 62 schizophrenia patients and 33 healthy subjects from Dutch descent. Bisulphite converted DNA from the 96 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Publication: Steve Horvath, Yafeng Zhang, Peter Langfelder, René S. Kahn, Marco P.M. Boks, Kristel van Eijk, Leonard H. van den Berg, Roel A. Ophoff. Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biology. Special Edition. The raw data (non-normalized Unmethylated and Methylated signal intensities) are not available.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath 

PROVIDER: E-GEOD-41169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Aging effects on DNA methylation modules in human brain and blood tissue.

Horvath Steve S   Zhang Yafeng Y   Langfelder Peter P   Kahn René S RS   Boks Marco P M MP   van Eijk Kristel K   van den Berg Leonard H LH   Ophoff Roel A RA  

Genome biology 20121003 10

<h4>Background</h4>Several recent studies reported aging effects on DNA methylation levels of individual CpG dinucleotides. But it is not yet known whether aging-related consensus modules, in the form of clusters of correlated CpG markers, can be found that are present in multiple human tissues. Such a module could facilitate the understanding of aging effects on multiple tissues.<h4>Results</h4>We therefore employed weighted correlation network analysis of 2,442 Illumina DNA methylation arrays  ...[more]

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