Whole genome profile of SWNCT and MWCNT vs. asbestos subchronic exposures to human small airway epithelial cells

ABSTRACT: Recent in vivo studies reported that inhaled carbon nanotube distribute in the alveolar region resulting in an acute inflammation, progressive fibrotic response and particle accumulation at the bronchoalveolar junction with low clearance. With similar biopersistence and shape as asbestos, a known lung carcinogen, growing concern has arisen for elevated risk of carbon nanotube-induced lung carcinogenesis; however few studies have evaluated long-term human health risks associated with chronic pulmonary carbon nanotube exposures compared to asbestos. To address this knowledge gap, we conducted subchronic in vitro exposures of dispersed single walled carbon nanotube, multi-walled carbon nanotube and crocidolite asbestos to human small airway epithelial cells to assess their neoplastic transfo

ORGANISM(S): Homo sapiens

SUBMITTER: Todd Stueckle 

PROVIDER: E-GEOD-41178 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress