High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development (aCGH)

ABSTRACT: Prostate cancer discovery and translational research are hampered by a lack of preclinical models which accurately reproduce the biological heterogeneity observed in patients. Accordingly, we have established a bank of transplantable patient-derived prostate tumor xenograft lines, using subrenal capsule grafting of human tumor tissue into immuno-deficient mice. This panel includes the first lines generated from primary prostate cancer tissue, and also new lines from metastatic tissue. Critically, the lines retained salient features of the original patient tumors, including histopathology, clinical marker expression, chromosomal aberration and gene expression profiles. Furthermore, they span major histopathological and molecular subtypes of prostate cancer, capturing diverse inter- and intr

ORGANISM(S): Homo sapiens

SUBMITTER: Shawn Anderson 

PROVIDER: E-GEOD-41188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress