Transcription profiling of human normal, benign, borderline malignant and malignant ovarian tissue

ABSTRACT: The Homeobox (HOX) family of genes encodes transcription factors involved in basic developmental processes, most notably during embryogenesis. A possible HOX gene link between development and oncogenesis has recently been described. Dysregulation of HOX genes may be an early event in malignant transformation likely to induce antibody response and thus provide a potential marker for early diagnosis of cancer. Ovarian cancer is characterized by poor early detection and serves as an excellent model system to develop potential markers for early diagnosis. In this study we begin to characterize HOX gene expression in malignant tumors of the ovary and analyze the potential role of HOX genes as biomarkers for early detection of ovarian cancer. Microarray analysis of mRNA from human ovarian tissue

ORGANISM(S): Homo sapiens

SUBMITTER: Zahra Bahrani Mostafavi 

PROVIDER: E-GEOD-4122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress