Transcription factors interfering with dedifferentiation induce direct conversion

ABSTRACT: Although transcription factor(TF)s regulate differentiation-related processes, including dedifferentiation and direct conversion, functional interactions between TFs regulating these processes are not well understood. Here we show that TFs preventing dedifferentiation are able to induce direct conversion. Using a neural lineage cell line and a large number of TFs expressed in it, we found a subset of TFs whose overexpression strongly interfered with dedifferentiation triggered by a procedure to induce induced pluripotent stem cells (iPSC), through a maintenance mechanism of the cell-type-specific transcriptional profile. Strikingly, the maintenance activity of the interfering TF set was strong enough to induce the cell line-specific transcriptional profile when overexpressed in a heterolog

ORGANISM(S): Mus musculus

SUBMITTER: Akira Watanabe 

PROVIDER: E-GEOD-41252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress