Deep RNA sequencing reveal a complex transcriptional landscape of a bat adenovirus.

ABSTRACT: Bat adenoviruses are a group of recently identified adenoviruses (AdVs) which are highly prevalent in bats yet share low similarity to known AdVs from other species. In this study, deep RNA sequencing was used to analyze the transcriptome at five time points following the infection of a bat AdV in a kidney cell line derived from a myotis bat species. Evidence of AdV replication was observed with the proportion of viral RNAs ranging from 0.01% at 6 h to 1.3% at 18 h. Further analysis of viral temporal gene expression revealed three replication stages; the early stage genes encoding mainly for host interaction proteins, the intermediate stage genes for the DNA replication and assembly proteins, and the late stage genes for most structural proteins. Several bat AdV genes were expressed at sta

ORGANISM(S): Myotis davidii

SUBMITTER: Lijun Wu 

PROVIDER: E-GEOD-41275 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress