A next generation sequencing approach to profiling the host miRNA response to a bovine mastitis pathogen

ABSTRACT: Substantial evidence is now beginning to emerge that miRNAs, short, non-coding RNAs, which post-transcriptionally regulate gene expression, play a key role in the regulation of innate and adaptive immunity in humans and mice. Little is currently known, however, regarding the importance miRNAs in regulating the host response to infection in agriculturally important animals, such as cattle. Mastitis is an inflammatory disease of the mammary gland caused either by infection or physical damage, which is associated with substantial economic losses. In this study, we report a next generation sequencing approach to profile the expression of bovine miRNAs in primary bovine mammary epithelial (BMEs) cells challenged with a bovine mastitis pathogen, Streptococcus uberis (0140J). Computational analys

ORGANISM(S): Bos taurus

SUBMITTER: Nathan Lawless 

PROVIDER: E-GEOD-41278 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress