Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.

ABSTRACT: Mitochondria control bioenergetics and cell fate decisions, but whether they also participate in extra-organelle signaling is not understood. Here, we show that interference with cyclophilin D (CypD), a mitochondrial matrix protein and apoptosis regulator, causes accelerated cell proliferation and enhanced cell migration and invasion. These responses are associated with global transcriptional changes in CypD-/- cells, predominantly affecting chemokines and their receptors, and resulting in increased activating phosphorylation of Signal Transduction and Activator of Transcription 3 (STAT3). In turn, STAT3 signaling promotes increased proliferation of CypD-/- cells via accelerated S-phase entry and supports Cxcl12-directed paracrine cell motility. Therefore, mitochondria-to-nuclei transc

ORGANISM(S): Mus musculus

SUBMITTER: Louise Showe 

PROVIDER: E-GEOD-41280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress