Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

ABSTRACT: Bulk cancer cell populations are known to display distinct metabolic properties compared to their normal counterparts. However, relatively little is known about heterogeneity of metabolic properties within tumors. In this study we show that, analogous to some normal stem cells, breast tumor initiating cells (TICs, also called cancer stem cells) have distinct metabolic properties compared to non-tumorigenic cancer cells (NTCs). Transcriptome profiling using RNA-Seq revealed TICs under-express genes involved in mitochondrial oxidative phosphorylation and although TICs are relatively quiescent, they preferentially perform glycolysis over oxidative phosphorylation compared to NTCs. TICs contain fewer mitochondria and display lower expression and activity of pyruvate dehydrogenase (Pdh), a key

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Gentles 

PROVIDER: E-GEOD-41286 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress