Characterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells

ABSTRACT: Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known to be a DNA-reactive substance which mainly induces chromosomal damage in cultured mammalian cells. However, there has been concern that FA might also act as an aneugen (i.e., induce aneuploidy) but recent cytogenetic studies did not support this assumption. To further characterize FA's genotoxic mode of action, we now used gene e

ORGANISM(S): Homo sapiens

SUBMITTER: Karlheinz Holzmann 

PROVIDER: E-GEOD-41296 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress