Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (expression)

ABSTRACT: The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated with altered development of placental trophoblast. We hypothesized that oxygen tension, vitamin D levels, or both affect villous trophoblast by modulation of gene expression through DNA methylation. To test this we used the Illumina Infinium Human Methylation 450 BeadChip array to compare the DNA methylation profile of primary cultures of human cytotrophoblasts and syncytiotrophoblasts under three oxygen tensions and three vitamin D levels. We found no effect on global DNA methylation by either tre

ORGANISM(S): Homo sapiens

SUBMITTER: John Blair 

PROVIDER: E-GEOD-41331 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress