Transcription profiling of S. cerevisiae cultures grown under low shear-modeled microgravity

ABSTRACT: The goal of this study was to assess whether low shear-modeled microgravity (LSMMG) effects yeast ,genomic expression patterns using the powerful tool of whole genome microarray hybridization. We determined ,changes in the yeast model organism, Saccharomyces cerevisisae, when grown in LSMMG using the rotating High ,Aspect Ratio Vessel (HARV). A significant number of genes were up- or down-regulated by at least two fold in cells ,that were grown for 5 generations or 25 generations in HARVs. We identified genes in cell wall integrity signaling ,pathways containing MAP kinase cascades that may provide clues to novel physiological responses of eukaryotic ,cells to the external stress of a low-shear modeled microgravity environment. A comparison of the microgravity ,response to other environme

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kate McInnerney 

PROVIDER: E-GEOD-4136 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress