Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor

ABSTRACT: A complex programme of regulation governs gene expression during development of the morphologically and biochemically complex eubacterial genus Streptomyces. Earlier work has suggested a model in which 'higher level' pleiotropic regulators activate 'pathway-specific' regulators located within chromosomal gene clusters encoding biosynthesis of individual antibiotics. We used mutational analysis and adventitious overexpression of key Streptomyces coelicolor regulators to investigate functional interactions among them. We report here that cluster-situated regulators (CSRs) thought to be pathway-specific can also control other antibiotic biosynthetic gene clusters, and thus have pleiotropic actions. Surprisingly, we also find that CSRs exhibit growth-phase-dependent control over afsR2/afsS, a

ORGANISM(S): Streptomyces coelicolor

SUBMITTER: Jane Huang 

PROVIDER: E-GEOD-4138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress