Histone H3K9 Methyltransferase G9a Represses PPAR? Expression and Adipogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shiliyang Xu
PROVIDER: E-GEOD-41457 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.
Wang Lifeng L Xu Shiliyang S Lee Ji-Eun JE Baldridge Anne A Grullon Sean S Peng Weiqun W Ge Kai K
The EMBO journal 20121123 1
PPARγ promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the mechanisms that control expression of these positive and negative master regulators of adipogenesis remain incompletely understood. By genome-wide histone methylation profiling in preadipocytes, we find that among gene loci encoding adipogenesis regulators, histone methyltransferase (HMT) G9a-mediated repressive epigenetic mark H3K9me2 is selectively enriched on the entire PPARγ locus. H3K9me2 and G9a levels decrea ...[more]
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