Expression data of A939572 SCD1 inhibitor treated ccRCC cells

ABSTRACT: Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. In order to understand the mechanism by which the SCD1 inhibitor mediated its anti-tumor effe

ORGANISM(S): Homo sapiens

SUBMITTER: Christina von Roemeling 

PROVIDER: E-GEOD-41485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress