Analysis of the humoral immune response against aberrant self by RNA sequencing of the fat body in Drosophila melanogaster

ABSTRACT: The early stages of the immune response against aberrant tissues such a tumors are technically difficult to study and therefore little understood. To analyze the innate immune response towards modified self-tissue we expressed a dominant-active version of the Ras oncogene in Drosophila imaginal discs and salivary glands. Signs of an immune response are observed on wings of adult flies, which show spots of melanization and in larvae, where the salivary glands attract blood cells. In line with the strong response mounted against salivary glands, they are found to express metalloproteases and apoptotic markers making them both accessible and recognizable for the immune system. The response against the glands bears several hallmarks of an encapsulation response including flattening of plasmato

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ulrich Theopold 

PROVIDER: E-GEOD-41487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress