Genome wide analysis of C57BL-6 mice infected with Chinese strain (SC84) of Streptococcus suis

ABSTRACT: Streptococcus suis is a major swine pathogen that can be transmitted to humans causing severe symptoms. A large human outbreak was described in China, where approximately 25% out of 215 infected humans developed an unusual streptococcal toxic shock-like syndrome (STSLS). Albeit increased expression of inflammatory mediators following infection by the Chinese S. suis strain was suggested as responsible for STSLS case severity, the mechanisms involved are still poorly understood. In this study, we investigated the host innate immune response to infection by either one of 3 strains of S. suis: 89-1591 (Canadian, intermediate virulence), P1/7 (European, high virulence), and SC84 (Chinese, epidemic strain). Using Illumina microarray and validating those results with qPCR and Luminex assay, infe

ORGANISM(S): Mus musculus

SUBMITTER: Claude Lachance 

PROVIDER: E-GEOD-41522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress