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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation)

ABSTRACT: A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me. Bisulphite converted DNA from the 8 samples were hybridised to the Illumina Infinium HM450 Human Methylation Beadchip

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaojing Yang

PROVIDER: E-GEOD-41525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (gene expression)

Project description:A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me. 24 Samples consisting of 3 cell lines hybridised to the Illumina HumanHT-12 V4.0 Beadchip.

2013-08-01 | E-GEOD-41676 | biostudies-arrayexpress

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation)

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