Role of platelet micrornas in sickle cell disease
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shilpa Jain
PROVIDER: E-GEOD-41575 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression of regulatory platelet microRNAs in patients with sickle cell disease.
Jain Shilpa S Kapetanaki Maria G MG Raghavachari Nalini N Woodhouse Kimberly K Yu Guoying G Barge Suchitra S Coronnello Claudia C Benos Panayiotis V PV Kato Gregory J GJ Kaminski Naftali N Gladwin Mark T MT
PloS one 20130412 4
<h4>Background</h4>Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications. The role for post-transcriptional regulation of the platelet transcriptome by microRNAs (miRNAs) in SCD has not been previously explored. This is the first study to determine whether platelets from SCD exhibit an altered miRNA expression profile.<h4>Methods and findings</h4>We analyzed the expression of miRNAs isolated from ...[more]
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