A master cistromic circuit governing hepatic fibrogenesis [expression array]

ABSTRACT: Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Expression profiling was used to explore the potential impact of VDR signaling in TGF?1 and TGF?1+1,25(OH)2D3-treated primary rat HSCs. Notably, 1,25(OH)2D3 treatment attenuated the culture-induced activation of HSCs, such that the transcriptome of treated cells closely resembled that of freshly isolated quiescent cells (Figure 2A), and co-treatment of 1,25(OH)2D3 together with TGF? resulted in considerable repression of a large set of TGF? induced genes. We also demonstrated that in primary mouse HSCs, calcipotriol potently repressed fibrotic gene e

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ruth Yu 

PROVIDER: E-GEOD-41579 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress