Truncating mutations of STAG2 define a molecular subgroup of aneuploid bladder cancers with poor prognosis.

ABSTRACT: Aneuploidy is among the most common hallmarks of cancer, yet the underlying genetic mechanisms are still poorly defined. We have recently identified STAG2 as a gene that is mutated in human cancer and whose inactivation leads directly to chromosomal instability and aneuploidy. However, no single tumor type has yet been identified in which inactivation of a cohesin subunit represents a predominant mutational event. Here we used immunohistochemistry to screen a panel of 2,214 tumors from each of the major human tumor types to identify additional tumor types harboring somatic loss of STAG2. Strikingly, STAG2 expression was completely absent in 18% of urothelial carcinomas, the most common type of bladder cancer and the fifth most common cancer in the United States. DNA sequencing revealed tha

ORGANISM(S): Homo sapiens

SUBMITTER: David Solomon 

PROVIDER: E-GEOD-41581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress