Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae

ABSTRACT: Specific histone modifications play important roles in chromatin functions such as activation or repression of gene transcription. These participation must occur as a dynamic process, however, most of histone modification state maps reported to date only provide static pictures linking certain modification with active or silenced states. This study focused on the global histone modification variation that occurs in response to transcriptional reprogramming produced by a physiological perturbation in yeast. We have performed genome-wide chromatin immunoprecipitation analysis for eight specific histone modifications before and after of a saline stress. The most striking change is a quick deacetylation of lysines 9 and 14 of H3 and lysine 8 of H4 associated to repression of genes. Genes that

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Vicent Pelechano 

PROVIDER: E-GEOD-41587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress