Phf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity [ChIP-Seq]

ABSTRACT: Polycomb group proteins are transcriptional repressors that play essential roles in regulating genes required for differentiation and embryonic development. The Polycomb repressive complex 2 (PRC2) contains the methyltransferase activity for lysine 27 on histone 3 (H3K27me3), which is a docking site for the PRC1 complex and leads to gene repression. However, the role of other histone modifications in regulating PRC2 activity is just beginning to be understood. Here we show that direct recognition of histone H3 methylated at lysine 36 (H3K36me), an mark associated with activation, by the PRC2 subunit Phf19 is required for the full enzymatic activity of the PRC2 complex. We provide structural evidence for this interaction by nuclear magnetic resonance spectroscopy (NMR). Using genome-wide ch

ORGANISM(S): Mus musculus

SUBMITTER: Luciano Di Croce 

PROVIDER: E-GEOD-41589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress