MicroRNA expression profiling of colorectal normal mucosa, adenoma and adenocarcinoma tissues

ABSTRACT: Approximately two decades ago, Vogelstein and Fearon proposed the adenoma-carcinoma sequence of sporadic CRC development and illustrated the accumulation of genetic alterations during the stepwise progression, thereby providing a guideline for clinical practice. Although the detection and excision of precancerous lesions could prevent colorectal cancer and reduce mortality, 6% of adenomas will ultimately develop into colorectal cancer. Thus, this genetic model for colorectal tumorigenesis may not completely reflect the complex essence of the disease and whether the mode of initiation of the events in the multistep progression affects the outcome of CRC is still unknown. In this study, mRNA and miRNA expression profiling was performed with human colorectal tissues, including normal mucosa,

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaoyu Shi 

PROVIDER: E-GEOD-41655 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress