Gene expression analysis of a series of HER2+ of breast tumors

ABSTRACT: Abstract Motivation Breast cancer is a heterogeneous disease with distinct subtypes. Even within these subtypes differences at the molecular level are present which are reflected in variable responses to chemotherapy. We set out to identify genes associated with chemotherapy resistance by analyzing a set of HER2-positive breast cancers. Methods We collected, gene expression profiled and analyzed 60 HER2-positive breast tumor biopsies, obtained from patients scheduled to undergo neoadjuvant therapy. In addition to conventional supervised approaches for the detection of reporters of resistance, we report on a novel approach specifically tailored to the detection of small groups of resistant samples that show aberrant gene expression patterns. Results We propose a novel analytical approach t

ORGANISM(S): Homo sapiens

SUBMITTER: Jelle ten Hoeve 

PROVIDER: E-GEOD-41656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress