Gene expression changes associated with progression and response in chronic myeloid leukemia

ABSTRACT: Chronic myeloid leukemia (CML) is a hematopoetic stem cell disease with distinct biological and clinical features. The biological foundation of the stereotypical progression from chronic phase through accelerated phase to blast crisis is poorly understood. We used DNA microarrays to compare gene expression in 91 cases of CML in chronic (42 cases), accelerated (17 cases), and blast phases (32 cases). Three thousand genes were found to be significantly (p<10-10) associated with the progression from chronic to blast phase. A comparison of the gene signatures of chronic, accelerated, and blast phases suggest that the progression of chronic phase CML from chronic advanced phase (accelerated and blast crisis) CML is a two-step rather than a three-step process, with new gene expression changes oc

ORGANISM(S): Homo sapiens

SUBMITTER: Olivia Cheng 

PROVIDER: E-GEOD-4170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress