Different transcriptional strategies for zygotic genome activation in Drosophila [ChIP-Seq]

ABSTRACT: During animal development, a fertilized egg is initially under the control of maternal products and only starts zygotic transcription after several cell divisions. In animals such as Xenopus, zebrafish and Drosophila, a massive increase in zygotic transcription occurs during the mid-blastula transition (MBT), when cells shift from rapid, synchronous cell divisions without gap phases to prolonged asynchronous divisions. Before MBT, only a few so-called pre-MBT genes are expressed. How transcription is set up during these early stages is poorly understood. For example, paused RNA Polymerase (Pol II) is frequently found at developmental control genes in mammalian embryonic stem cells and Drosophila embryos but when Pol II pausing is first established in the embryo is unknown. We have analyzed

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jeff Johnston 

PROVIDER: E-GEOD-41700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress