Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Raymond Lo
PROVIDER: E-GEOD-41820 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Toxicological sciences : an official journal of the Society of Toxicology 20120817 2
The aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) activated complex regulates genes in response to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR has also emerged as a potential therapeutic target for the treatment of human diseases and different cancers, including breast cancer. To better understand AHR and ARNT signaling in breast cancer cells, we used chromatin immunoprecipitation linked to high-throughput sequencing to identify AHR- and AR ...[more]