Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway

ABSTRACT: Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with the expression profiling of protein- coding genes. miRNA profiling of medulloblastomas was carried out using Taqman Low Density Density Aarray v 1.0 having 365 human microRNAs. In parallel, genome--wide expression profiling of protein coding genes was carried out using Affymetrix gene 1.0 ST arrays. Both the profiling studies identified four molecular subtypes of medulloblastomas. Expression levels of select protein-coding genes and miRNAs could classify an independent set

ORGANISM(S): Homo sapiens

SUBMITTER: Neelam Shirsat 

PROVIDER: E-GEOD-41842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress