Neuropsychiatric and clinical correlates to miRNA expression in the frontal cortex of HIV-infected individuals

ABSTRACT: Objective: To elucidate molecular mechanisms of neurocognitive dysfunction in long-term HIV-infected individuals by assessing the microRNA (miR) profile and determining clinical and neurocognitive correlates to miR expression. Design: Analysis of miR profile in frontal cortex of retrospectively-identified autopsy cases of longitudinally-followed subjects with HIV-infection and age/sex-matched controls. HIV-subjects had semi-annual neuropsychiatric and clinical testing, at autopsy, tissue was archived. Methods: MiR repertoires were profiled from frontal cortices. Analysis of variance (ANOVA) and Tukey Honestly Sigificant Difference (HSD) tests with Benjamini-Hochberg correction for multiple comparisons were used to compare expression among the three groups. Pairwise correlations were

ORGANISM(S): Homo sapiens

SUBMITTER: Erick Tatro 

PROVIDER: E-GEOD-41952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress