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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genes associated with prostate cancer are differentially expressed in African American and European American men (tumor specimens)

ABSTRACT: A total of 1,507 probes measured the expression of 517 genes on the custom Illumina DASL assay testing if select genes showed cancer-specific differential expression according to race. Genes were chosen for inclusion in the assay based on existing evidence from the literature and our own data for their importance to prostate cancer, prostate cancer aggressiveness, or cancer in general. 639 FFPE tumor samples (270 African American, 369 European American)

ORGANISM(S): Homo sapiens

SUBMITTER: Aliccia Bollig-Fischer

PROVIDER: E-GEOD-41967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes associated with prostate cancer are differentially expressed in African American and European American men (matched normal specimens)

Project description:A total of 1,507 probes measured the expression of 517 genes on the custom Illumina DASL assay testing if select genes showed cancer-specific differential expression according to race. Genes were chosen for inclusion in the assay based on existing evidence from the literature and our own data for their importance to prostate cancer, prostate cancer aggressiveness, or cancer in general 163 FFPE tumor matched normal (control) samples (80 African American, 83 European American) were assayed

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2015-07-27 | E-GEOD-64318 | biostudies-arrayexpress

Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)

Project description:In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by tumor subtype, histological grade, and ethnicity (African-American, AA, compared to European-American, EA). DNA copy number alterations (CNAs) were analyzed on the Affymetrix Human SNP Array v 6.0 platform. The study provides insight into the genetic component of ethnicity-related breast cancer health disparities. DNA copy number alterations (CNAs) and genotypes were analyzed using the Affymetrix SNP 6.0 platform. Breast tumor samples from young women (< 50 years old) were matched as follows: a matched pair consists of one AA and one EA sample, matched for tumor grade and tumor subtype (based on immunohistochemical analysis of ER, PR, and HER2 status). DNA from forty-four samples (22 AA, 22 EA) was analyzed on the Affymetrix SNP 6.0 array according to manufacturer’s directions.

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Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

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Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)

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Genomic profiles vary with race and subtype in young African American and European American breast cancer (aCGH)

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Transcription profiling of human prostate cancer epithelial cells from African American and European American men

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