Gene-expression profile of Id2+ versus Id2KO KLRG1lo cells during infection

ABSTRACT: CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein transcription factors, Id2, is necessary for accumulation of effector and memory CD8+ T cells during infection. Here we show that CD8+ T cells lacking Id2 did not generate a robust terminally-differentiated KLRG1hi effector population, but displayed a cell-surface phenotype and cytokine profile consistent with memory precursors, raising the question as to whether loss of Id2 impairs the differentiation and/or survival of effector-memory cells. We found that deletion of Bim rescued Id2-deficient CD8

ORGANISM(S): Mus musculus

SUBMITTER: John Best 

PROVIDER: E-GEOD-41978 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress