Bone Marrow Monocyte/Macrophage Derived Activin A Mediates the Osteoclastogenic Effects of IL-3 in Myeloma

ABSTRACT: Myeloma bone disease is characterized by tremendous bone destruction with suppressed bone formation. IL-3 is a multifunctional cytokine that increases myeloma cell growth and osteoclast proliferation while inhibiting osteoblast differentiation. While IL-3 appears to be an attractive therapeutic target for myeloma, attempts at targeting IL-3 have been unsuccessful due to IL-3M-bM-^@M-^Ys effects on normal hematopoiesis. Thus identification of IL-3M-bM-^@M-^Ys downstream effects in MMBD is important for effective targeting of this cytokine in MM. Here we demonstrated that treatment of myeloma patient CD14+ bone marrow monocyte / macrophages with IL-3 induces high levels of Activin A (ActA), a pluripotent TGF-M-NM-2 superfamily member that, like IL-3, modulates MMBD by enhancing osteoclastoge

ORGANISM(S): Homo sapiens

SUBMITTER: Nicola Giuliani 

PROVIDER: E-GEOD-41992 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress