Allele-specific FKBP5 DNA demethylation: a molecular mediator of gene-childhood trauma interactions

ABSTRACT: While the paradigm that genetic predisposition and environmental exposures interact to shape development and function of the human brain and ultimately the risk of psychiatric disorders has drawn wide interest, the corresponding molecular mechanisms have not been elucidated yet. Here we show that a functional polymorphism altering chromatin interaction between the transcription start site and long range enhancers in the FK506 binding protein 5 (FKBP5) gene, an important regulator of the stress hormone system, increases the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma-dependent DNA demethylation in functional glucocorticoid response elements (GREs) of FKBP5. This demethylation is linked to increased stress-dependent gene transcrip

ORGANISM(S): Homo sapiens

SUBMITTER: Divya Mehta 

PROVIDER: E-GEOD-42002 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress