Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease

ABSTRACT: Expression data were generated on 136 subjects from the COPDGene® study using Affymetrix microarrays. Multiple linear regression with adjustment for covariates (gender, age, body mass index, family history, smoking status, pack years) was used to identify candidate genes and Ingenuity Pathway Analysis was used to identify candidate pathways. Candidate genes identified included those that play a role in the immune system, inflammatory responses, and sphingolipid metabolism. Many of our final candidate genes also show an association with related disease phenotypes such as emphysema, gas trapping, and 6-minute walk distance. 42 control subjects and 94 subjects with varying severity of COPD had PBMC gene expression profiles generated. All subjects are non-hispanic white, current or former smokers.

ORGANISM(S): Homo sapiens

SUBMITTER: Grant Hughes 

PROVIDER: E-GEOD-42057 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.

Bahr Timothy M TM   Hughes Grant J GJ   Armstrong Michael M   Reisdorph Rick R   Coldren Christopher D CD   Edwards Michael G MG   Schnell Christina C   Kedl Ross R   LaFlamme Daniel J DJ   Reisdorph Nichole N   Kechris Katerina J KJ   Bowler Russell P RP  

American journal of respiratory cell and molecular biology 20130801 2

Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only a fraction of smokers develop the disease. We hypothesized distinct molecular signatures for COPD and emphysema in the peripheral blood mononuclear cells (PBMCs) of current and former smokers. To test this hypothesis, we identified and validated PBMC gene expression profiles in smokers with and without COPD. We generated expression data on 136 subjects from the COPDGene study, using Affymetrix U133 2.0 mic  ...[more]

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