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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Hyperlipidemia impaired innate response

ABSTRACT: To explore the effect of hyperlipidemia on macrophages' innate immune response to Porphyromonas gingivalis invasion 12 samples, 3 replicates in 4 groups, with cells from hyperlipidemic ApoE deficient mice and nonhyperlipidemic C57BL/6 mice stimulate with or without P.gingivalis(Pg)

ORGANISM(S): Mus musculus

SUBMITTER: Lang Lei

PROVIDER: E-GEOD-42061 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hyperlipidemia impaired innate immune response to periodontal pathogen porphyromonas gingivalis in apolipoprotein E knockout mice.

Lei Lang L Li Houxuan H Yan Fuhua F Xiao Yin Y

PloS one 20130816 8

A finely-tuned innate immune response plays a pivotal role in protecting host against bacterial invasion during periodontal disease progression. Hyperlipidemia has been suggested to exacerbate periodontal health condition. However, the underlying mechanism has not been addressed. In the present study, we investigated the effect of hyperlipidemia on innate immune responses to periodontal pathogen Porphyromonas gingivalis infection. Apolipoprotein E-deficient and wild-type mice at the age of 20 we ...[more]

PMID: 23977160

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