Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of HuntingtonM-bM-^@M-^Ys disease

ABSTRACT: Abstract - Huntingtin (Htt) protein interacts with many transcriptional regulators, with widespread disruption to the transcriptome in HuntingtonM-bM-^@M-^Ys disease (HD) brought about by altered interactions with the mutant Htt (muHtt) protein. Repressor Element-1 Silencing Transcription Factor (REST) is a repressor whose association with Htt in the cytoplasm is disrupted in HD, leading to increased nuclear REST and concomitant repression of several neuronal-specific genes, including brain-derived neurotrophic factor (Bdnf). Here, we explored a wide set of HD dysregulated genes to identify direct REST targets whose expression is altered in a cellular model of HD but that can be rescued by knock-down of REST activity. We found many direct REST target genes encoding proteins important for

ORGANISM(S): Mus musculus

SUBMITTER: Caroline Johnston 

PROVIDER: E-GEOD-42107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress