Mechanism of cell death induced by saporin

ABSTRACT: Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av. Delivery of saporin into cancer cells by ch128.1Av, induces a transcriptional response consistent with oxidative stress and DNA damage, a response that is not observed with ch128.1Av alone. Time course, after delivery of saporin into cells by ch128.1Av

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Penichet 

PROVIDER: E-GEOD-42138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress