Gene expression in signaling subsets of AML blasts induced by G-CSF

ABSTRACT: While the response to G-CSF is a significant predictor of AML outcome, the nature of cells responding differentially to this and other cytokines remains unclear. Based on gene expression signatures observed in G-CSF Responsive Cells (RC) and non-G-CSF Responsive Cells (NRC) a cohort of AML samples were segregated into two types. In Type1 both cell subsets displayed an undifferentiated phenotype. In the Type2 AML the RC showed a very similar undifferentiated progenitor-like phenotype as in Type1 RC, whereas the NRC exhibited a more differentiated hematopoietic phenotype. The frequency of RC per sample was a determinant of whether a patient belonged to Type1 or Type2. Type2 RC had higher expression of CD321, higher colony formation capacity and greater responsiveness to cytokines secreted b

ORGANISM(S): Homo sapiens

SUBMITTER: Yury Goltsev 

PROVIDER: E-GEOD-42140 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress