IL-21 regulates the expression of chemokine genes in B-chronic lymphocytic leukemia

ABSTRACT: B-cell chronic lymphocytic leukemia (CLL) is a common type of leukemia, characterized by the progressive accumulation of CD5+ “mature” monoclonal B lymphocytes in peripheral blood, bone marrow and lymphoid tissues. Although circulating CLL cells are non-dividing cells, prone to spontaneous apoptosis, their progressive accumulation is the result of a dynamic balance between cell death and proliferation and a high turn-over rate has been related to a poor prognosis. Indeed, CLL cells are protected from apoptosis and proliferate in specific niches within the lymphoid tissues and the bone marrow. CLL cells show variable expression of IL-21R that can be up-regulated by cell activation via CD40. CD40-activated CLL cells phosphorylate STAT-1 and STAT-3 and undergo apoptosis in response to IL-21 s

ORGANISM(S): Homo sapiens

SUBMITTER: Loris De Cecco 

PROVIDER: E-GEOD-42158 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress