Cavin1 Deficiency Alters Lung macrophage homeostasis in Mouse

ABSTRACT: Caveolae are cell membrane invaginations that are highly abundant in adipose tissue, endothelial cells and lung and are present at lower levels in other tissues. The formation of caveolae is dependent of the expression of various structural proteins that serve as scaffolding for these membrane invaginations. Cavin1 is a newly identified structural protein whose deficiency leads to absence of caveolae formation and to the development of a lipodystrophic phenotype. In this study we show Cavin1 expression is critical for regulating macrophage number and gene-expression (phenotype) in the lung. We used microarrays to detail the global programme of gene expression in alveolar macrophage in a Cavin1 knock-out mouse and identified distinct classes of dysregulated genes during this process. Bronch

ORGANISM(S): Mus musculus

SUBMITTER: Adam Gower 

PROVIDER: E-GEOD-42169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress