Gene expression profile in melanomas from Pdk1-inactivated BrafV600E::Pten-/- mice

ABSTRACT: Gene expression profiling was performed to access the changes in gene expression in melanomas from Pdk1-inactivated Brafv600E::Pten-/- mice. The expression profiles of the BrafV600E::Pten-/-::Pdk1-/- were compared to the BrafV600E::Pten-/-::Pdk+/+ genotypes. The analysis has identified several important signaling pathways in Pdk1-dependent melanomagenesis. Melanoma tumors from the BrafV600E::Pten-/-::Pdk1+/+ and BrafV600E::Pten-/-::Pdk1-/- genotypes were harvested and mRNA from each group was pooled to enable four biologically replicates analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Jian-Liang Li 

PROVIDER: E-GEOD-42187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress