Adenoviral shRNA-based knockdown of hepatic Tcf2 (Ad-shTcf2)

ABSTRACT: Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus (T2D) and in the pathogenesis of obesity-associated disturbances of glucose and lipid metabolism 1,2,3. MicroRNA (miR)-dependent posttranscriptional gene silencing has recently been recognized to control gene expression in disease development and progression including that of insulin-resistant T2D. MiRs, whose deregulation alters hepatic insulin sensitivity include miR-143, miR-181 and miR-103/107. Here we report that expression of miR-802 is increased in liver of two obese mouse models and of obese human subjects. Inducible transgenic overexpression of miR-802 in mice causes impaired glucose tolerance and attenuates insulin sensitivity, while reduction of miR-802 expression improves glucose toleran

ORGANISM(S): Mus musculus

SUBMITTER: Jan-Wilhelm Kornfeld 

PROVIDER: E-GEOD-42188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress