Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages

ABSTRACT: When macrophages are activated by sensing bacterial lipopolysaccharides (LPS), they greatly increase their motility, mRNA synthesis and protein production. Most of the ATP needed for these responses is derived from the uptake and catabolism of glucose, a relatively inefficient ATP source. Although the stimulated cells also increase their uptake of free fatty acids, they store a large fraction as triglycerides (TAG). We report here that both Toll-like receptor 4 (TLR4) and TLR2 agonists stimulate prolonged TAG retention by primary murine and human macrophages. Agonist-induced TAG storage lasted at least 72-96 hrs in vitro and was associated with increases in fatty acid (FA) uptake, FA esterification, and FA incorporation into TAG; FA oxidation decreased. The results of expression an

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Myers 

PROVIDER: E-GEOD-42190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress