Vitamin C Stimulon in Mycobacterium tuberculosis

ABSTRACT: The emergence of drug resistance among tuberculosis (TB) patients is often associated with their non-compliance to the length of the chemotherapy, which can reach up to 2 years for the treatment of multi-drug-resistant (MDR) TB. Drugs that would kill TB faster and would not lead to the development of drug resistance could shorten chemotherapy significantly. In Escherichia coli, the common mechanism of cell death by bactericidal antibiotics is the generation of highly reactive hydroxyl radicals via the Fenton reaction. Since ascorbic acid (vitamin C) is known to drive the Fenton reaction, we tested whether the Fenton reaction could lead to a bactericidal event in Mycobacterium tuberculosis by treating M. tuberculosis cultures with vitamin C. Here, we report that the addition of vitamin C

ORGANISM(S): Mycobacterium tuberculosis H37Rv

SUBMITTER: Brian Weinrick 

PROVIDER: E-GEOD-42293 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress