Dataset Information
Transcription profiling of liver from mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 at 0.5 to 48 hours after INFg treatment
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sam Wormald
PROVIDER: E-GEOD-4232 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling.
The Journal of biological chemistry 20060210 16
Negative feedback is a mechanism commonly employed in biological processes as a means of maintaining homeostasis. We have investigated the roles of suppressor of cytokine signaling (SOCS) proteins in regulating the kinetics of negative feedback in response to cytokine signaling. In mouse livers and bone marrow-derived macrophages, both interferon-gamma (IFNgamma) and interleukin-6 (IL-6) rapidly induced the tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT1) an ...[more]
