Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene Expression Profile of 53 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)

ABSTRACT: To analyze the prognostic relevance of transcriptional profiling in adult T-ALL, we analyzed a clinical series of 53 primary leukemia samples uniformly treated according to the ECOG E2993 protocol using gene expression oligonucleotide microarrays. Unsupervised analysis and consensus clustering of microarray gene expression data in this series revealed the presence of 2 stable gene expression clusters corresponding to early immature (n = 28) and cortical/mature (n = 25) adult T-ALLs respectively. Early immature T-ALLs show a gene expression signature related to hematopoietic stem cells and myeloid progenitors that was recently linked to a group of childhood T-ALLs with poor prognosis. Notably, univariate analysis in our patient series confirmed that early immature adult T-ALL is associated with poor prognosis and reduced overall survival compared with cortical/mature adult T-ALL (P = 0.0197) 53 adult T-ALL samples were analyzed

ORGANISM(S): Homo sapiens

SUBMITTER: Alberto Ambesi-Impiombato 

PROVIDER: E-GEOD-42328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic alterations, immunophenotypic markers, and microarray gene expression signatures in a panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993 clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG deletion, CD13 surface expression, heterozygous deletio  ...[more]

Similar Datasets

Transcriptomics Gene Expression Profile of 53 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
2013-08-02 | GSE42328 | GEO
Transcriptomics Gene Expression Profile of 57 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
2011-11-05 | E-GEOD-33469 | biostudies-arrayexpress
Transcriptomics Gene expression analysis of Early immature and Late mature T-ALL cell lines
2013-06-18 | GSE48046 | GEO
Transcriptomics Gene expression analysis of Early immature and Late mature T-ALL cell lines
2013-06-18 | E-GEOD-48046 | biostudies-arrayexpress
Transcriptomics Gene Expression Analyisis of T-ALL LOUCY cell lines treated with ETV6 siRNA vs. scramble control siRNA
2011-11-24 | GSE33820 | GEO
Transcriptomics Transcriptomic analysis of Acute Myeloid Leukemia and T Acute Lymphoblastic Leukemia
2019-12-09 | GSE131184 | GEO
Transcriptomics Gene Expression Analyisis of T-ALL LOUCY cell lines treated with ETV6 siRNA vs. scramble control siRNA
2011-11-24 | E-GEOD-33820 | biostudies-arrayexpress
Transcriptomics Gene expression signatures of 64 T-ALL patient diagnosis samples
2014-10-14 | E-GEOD-62156 | biostudies-arrayexpress
Methylation profiling Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukemia
2012-11-07 | GSE39141 | GEO
Transcriptomics Gene expression signatures of 64 T-ALL patient diagnosis samples
2014-10-14 | GSE62156 | GEO