Nitric Oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

ABSTRACT: JS-K, a NO donor which capable to induce cancer apopotosis, it's killing mechanism was investigated in this study. We found out that JS-K induce apopotosis via deregulating the GSH/GSSG redox couple. Leukemia cells were treated with JS-K and then assayed for metabolic changes by LC/MS and gene expression alterations by microarray.

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Cheng 

PROVIDER: E-GEOD-42344 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress