Comprehensive, high resolution analysis of cis-acting regulatory networks at the alpha globin locus
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Gibbons
PROVIDER: E-GEOD-42384 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
Hughes Jim R JR Lower Karen M KM Dunham Ian I Taylor Stephen S De Gobbi Marco M Sloane-Stanley Jacqueline A JA McGowan Simon S Ragoussis Jiannis J Vernimmen Douglas D Gibbons Richard J RJ Higgs Douglas R DR
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20130506 1620
We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the cis-regulatory elements controlling a single gene or gene cluster. Using the human α-globin locus as a ...[more]
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