Effect of rBTNL2.Fc co-stimulation on murine CD4+ cells

ABSTRACT: Naïve T cell activation involves at least two signals from an antigen presenting cell (APC), one through the T cell receptor via interaction with APC peptide-MHC complexes and a second through interaction of CD28 with APC B7 ligands. Following activation, T cells up-regulate a host of other membrane-bound costimulatory molecules which can either promote or inhibit further T cell maturation and proliferation. In some cases, it is necessary to attenuate T cell activation to prevent deleterious inflammation, and inhibitory members of the B7/Butyrophilin family of ligands have evolved to balance the strong stimuli the activating B7 ligands confer. Human genetic association and in vitro studies have implicated one such ligand, BTNL2, in controlling inflammation at mucosal surfaces. Here we

ORGANISM(S): Mus musculus

SUBMITTER: Jeannette Bigler 

PROVIDER: E-GEOD-42385 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress